The collaborative mission of the Transplantation Research Center (TRC) at Brigham and Women’s Hospital (BWH) and Children’s Hospital Boston (CHB) is to provide comprehensive care to enhance the safety and long-term success of organ transplantation by connecting the areas of clinical care and treatment, surgical practice, technology, drug development, and laboratory research. The Center’s ultimate goal is to make every transplant a success that lasts a lifetime. The TRC will involve patients in care improvement projects and research, and transform the way we approach transplantation medicine. This approach to treatment allows us to take what we learn at the patient bedside and bring that information back to the lab bench to try new theories and ideas. This cycle is completed when treatment approaches developed in the research setting are implemented in clinical practice. Occupying more than 12,000 square feet of space at both BWH and CHB, we are in a strong position to assume this leadership role. We not only pioneered transplantation medicine, we intend to do it better than anyone else.