The Transplantation Research Center is located in the Longwood Medical Area (LMA) of Boston, Massachusetts .  The 213-acre LMA represents one of the premier medical, research and academic communities in the world.  More than 37,000 people staff the area’s institutions; 15,000 students attend classes in the district.  Moreover, eastern Massachusetts is one of the hotbeds of activity for the pharmaceutical and biotechnology industries. 


As a consequence of its location in this dense and vibrant community, the TRC is ideally situated to take advantage of both world-class facilities and the opportunity for almost unlimited scientific collaboration.  We are also able to access the many core instrumentation facilities sited in the LMA, including some of the most advanced and sensitive analytical tools available. 


The research facilities of the Center itself are sited at two locations (see Contact Us) – Brigham and Women’s Hospital and Children’s Hospital Boston, totaling nearly 13,000 square.  Of this total, 7000 square feet are devoted to wet lab for basic research.  Other major allocations for space include office suites, dedicated and shared support areas and conference rooms. 


Specialized work zones have been established for cell culture [including a BL2+ facility for gene therapy projects], in vitro cellular and molecular analyses, microscopy, cold rooms and radioisotope handling.  Projects involving in vivo models of transplantation are carried out in nearby virus-free facilities with adjacent dedicated procedure rooms and expertly trained support staff. 


We have made a significant investment in instrumentation that enables us to perform expression profiling in a number of dimensions of relevance to immunologic research.  The Center operates two FACSCalibur flow cytometers, ELISpot [highly sensitive detection of reactive immune cells], thermal cyclers for quantitative PCR, and a Luminex instrument for multiplex analyses of soluble ligands and nucleic acids.  This array of instrumentation, and more, may be made available to members of the LMA community upon application. 


Our research is very computer-intensive, especially with regard to expression profiling.  We are served by broadband network connectivity and supported by research computing staff at both institutions.  As a result, TRC has extensive dedicated server space and is afforded automatic nightly file backups for data protection.  In addition, the many Harvard University libraries and other cyber resources are available at the desktop of every investigator.


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