Instructor of Medicine, Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Harvard Medical School
After 5 years surgical residency in Japan, Dr. Ueno received a board from the Japan Surgical Society in 1999. He started his Ph.D. program from 2001 in . The main theme was `organ preservation` and he received his Ph.D. in 2005. In 2003, he moved to Boston to start another postdoctoral fellowship in the Transplantation Unit, Surgery, Massachusetts General Hospital under the supervision of Dr. Auchincloss, as well as in the Transplantation Research Center , Renal Division, Brigham and Women’s Hospital under the supervision of Dr. Sayegh. He has performed about 1,200 cardiac txs. in mice for several projects. In 2007, he returned to the Critical Care Medicine of Tokyo Medical University, Tokyo, . He focused on patients with hypercytokinemia such as sepsis, acute abdomen, peritonitis, transplantation (liver, kidney), and MOF. He has made over 10 presentations including being an invited speaker as one of the pioneer of PMX-DHP adsorbing mediators, cytokines and endotoxin. Therefore, he is the only Japanese co-author of its first systematic review published in Critical Care 2007 and serves as reviewer of a couple of medical journals and has received awards.
Recently Dr. Ueno returned to TRC, Renal Division, Brigham and Women’s Hospital and has started several projects with his colleagues again. Also he is attending operations at MGH once a week.
Awards:
2002 - 13th Annual Meeting of Japan Society for Blood Purification in Critical Care 2004 - 6th Japanese Society for Abdominal Emergency Medicine 2005 - American Transplant Congress, Poster of distinction
Dr. Ueno served as
2005 Reviewer (Artificial Organs)
2005 Reviewer (Therapeutic Apheresis and Dialysis)
Takuya's research interests
Dr. Ueno’s research interests focused on investigation of studying the mechanisms of allograft rejection and transplantation tolerance using cardiac transplantation models. Recently Dr. Ueno and his colleagues have shown new insights of unknown functions of TIM-1 in regulating alloimmune responses. Therefore, to evaluate the role of the pathway between TIM-1 and its ligand TIM-4 is our future direction. Also he is interested in pathways in the B7:CD28 family. Dr. Ueno and his colleagues have defined the inhibitory functions of the novel costimulatory molecule B7-H3 in alloimmune responses. This project is now preparing for submission. Furthermore, Dr. Ueno is interested in chemokines; possible therapeutic targets in transplantation. He is examining several projects with his colleagues.
E-Mail: tueno@rics.bwh.harvard.edu
Place of Birth: Minato-ku, Tokyo, JAPAN
Education: Kitasato University School of Medicine, Kitasato University Graduate School of Medical Science
Year Degree Institution: 1989-1995, 2001-2005
For graduate degrees, note field or discipline: M.D.(1995~), Ph.D.(2005~)
Postdoctoral Training:
2001 - 2005 Kitasato University Hospital, Department of Surgery, Japan (transplant surgery)
2003 - 2006 Massachusetts General Hospital, Boston, MA (transplant surgery)
2003 - 2006 Brigham and Women’s Hospital, Boston, MA (transplant surgery)
Internships, residencies, clinical and research fellowships:
May 1995-Mar 1996 Junior Resident Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
Apr 1996-Mar 1998 Junior Resident, Senior Resident Department of Surgery, National Sagamihara Hospital Sagamihara, Kanagawa, Japan
Apr 1998-Mar 1999 Senior Resident Department of Surgery, Kitasato University Hospital, Kanagawa, Japan
Apr 1999-Mar 2001 Senior Resident , Chief Resident Department of Surgery, Asoka Hospital, Koto, Tokyo, Japan
Jan 2007-Mar 2008 Instructor Critical Care Medicine, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan
Licensure and Certification:
Dec 1999. Authorized Doctor (Japan Surgical Society): No.14392
Dec 2002. Medical Specialist (The Japanese Society of Gastroenterology): No.27064
Dec 2003. Medical Specialist (Japan Surgical Society): No.1908126
Academic Appointments:
July 2003- June 2006 Research Fellow Transplantation Unit, Surgery, Massachusetts General Hospital, Harvard Medical School
July 2003- December 2006 Research Fellow Transplantation Research Center, Brigham and Women’s Hospital, Harvard Medical School
Apr 2008- Present Instructor Transplantation Research Center, Brigham and Women’s Hospital
Harvard Medical School
Hospital or Affiliated Institution Appointments:
Apr 2001- June 2003 Research Fellow Kitasato University Hospital Department of Surgery
Professional Societies:
1995 Japan Surgical Society (member)
1995 Japan Surgical Association (member)
1996 The Japanese Society of Gastroenterological Surgery (member)
1996 The Japanese Society of Gastroenterology (member)
1997 Japan Society for Endoscopic Surgery (member)
1998 Japanese Society for Abdominal Emergency Medicine (member)
1999 Japan Gastroenterological Endoscopy Society (member)
2003 Japan Society for Transplantation (member)
2003 Japan Society for Blood Purification in Critical Care (member)
2004 The Japanese Society of Intensive Care Medicine (member)
2007 Japanese Association for Acute Medicine (member)
2008 The American Society of Transplantation (member)
Editorial Boards:
1999 Authorized Doctor (Japan Surgical Society): No.14392
2002 Medical Specialist (The Japanese Society of Gastroenterology): No.27064
2003 Medical Specialist (Japan Surgical Society): No. 1908126
2005 Reviewer (Artificial Organs)
2005 Reviewer (Therapeutic Apheresis and Dialysis)
Awards and Honors:
2002 - 13th Annual Meeting of Society for Blood Purification in Critical Care
2004 - 6th Japanese Society for Abdominal Emergency Medicine
2005 - American Transplant Congress, Poster of distinction
Part II: Research, Teaching, and Clinical Contributions:
Narrative report
Clinical/Research: After 5yrs residency of general surgery, I received a board from Japan Surgical Society as an authorized surgeon and started my research fellowship at Kitasato University Graduate School of Medical Science from 2001. My research interest focused on organ preservation in liver transplantation. We have demonstrated (-3 degrees) nonfrozen conditions have sufficient function to sustain the life of rats after orthotopic liver transplantation and also succeeded in the model of orthotopic liver transplantation using liver grafts from12hrs brain death donors.
From 2003, I moved to Boston, MA and investigated to understand mechanisms of T cell recognition of alloantigen in Massachusetts General Hospital under the supervision of Dr. Auchincloss. At the TRC, I was able to delineate the role of specific T cell costimulatory activation pathways in graft rejection and tolerance using several different molecules such as TIM-1, B7-H3 as well as some of the negative T cell costimulatory pathways. While in Japan, I also gain experience working at Critical Care Medicine and Surgical ICU of Tokyo Medical University, Tokyo, JAPAN where I focused on patients with hypercytokinemia such as sepsis. We have shown the beneficial effects of polymyxin B-immobilized fiber column in septic patients.
Regional, National, or International Contributions:
2003
Oral presentation
Japanese Liver Transplantation Society, Nagasaki, Japan
Japan Surgical Society, Sapporo, Japan
2004
Oral presentation
American Transplant Congress, Boston, MA,
2005
Oral presentation
American Transplant Congress, Seattle, WA, U.S.A
2006
Oral presentation
World Transplant Congress, Boston, MA, U.S.A
Oral presentation
ASN Renal Week, San Diego, CA, 2007 Poster presentation
American Transplant Congress, San Francisco, CA, U.S.A
Part III: Bibliography
［Articles］
1. Ueno T, Tanaka K, Jurewicz M, Murayama T, Guleria I, Fiorina P, Jesus PC, Augello A, Vergani A, Wong M, Smith RN, Abdi R. Divergent role of tissue/donor dendritic cells in rejection versus tolerance of vascularized cardiac allografts: studies with CX3CR1-deficient and B6.FVB-Tg (Itgax-DTR/EGFP) 57Lan/J mice. J Am Soc Nephrol. in press.
2. Habicht A, Ueno T, Clarkson MR, D’Addio F, Freeman GJ, Sayegh MH, Ansari MJ. A Novel CD160Ig Fusion Protein Inhibits Alloimmune Responses. J Immunol. in submission.
3. Ueno T, Habicht A, Clarkson MR, Albin MJ，Yamaura K, Boenisch O, Popoola J, Wang Y, Yagita H, Akiba H, Ansari MJ, Yang J, Turka LA, Rothstein DM, Padera RF, Sayegh MH, Najafian N. The emerging role of T-cell immunoglobulin mucin 1 (TIM-1) in alloimmune responses in vivo. J Clin Invest, 2008;118(2):742-51.
4. Izawa A＊, Ueno T＊, Jurewicz M, Ito T, Tanaka K, Takahashi M, Ikeda U, Sobolev O, Fiorina P, Smith RN, Hynes RO, Abdi R. Importance of Donor- and Recipient-Derived Selectins in Cardiac Allograft Rejection. J Am Soc Nephrol. 2007 Nov;18(11):2929-36. ＊; equal contribution
5. Tanaka K, Albin MJ, Yuan X, Yamaura K, Habicht A, Murayama T, Grimm M, Waaga AM, Ueno T, Padera RF, Yagita H, Azuma M, Shin T, Blazar BR, Rothstein DM, Sayegh MH, Najafian N. PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection.
J Immunol. 2007; 179: 5204-5210.
6. Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH. Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice. Clin Immunol. 2007 Sep 20; [Epub ahead of print]
7. Smith RN, Ueno T, Ito T, Tanaka K, Shea SP, Abdi R. Chemokines and chronic heart allograft rejection. Transplantation. 2007; 84: 442-4.
8. Izawa A, Yamaura K, Albin MJ, Jurewicz M, Tanaka K, Clarkson MR, Ueno T, Habicht A, Freeman GJ, Yagita H, Abdi R, Pearson T, Greiner DL, Sayegh MH, Najafian N. A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo. J Immunol. 2007;179: 786-96.
9. Lacy-Hulbert A＊, Ueno T＊, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H Jr, Sayegh MH, Hynes RO, Abdi R. Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection. Am J Transplant. 2007; 7: 1080-90. ＊; equal contribution
10. Cruz DN, Perazella MA, Bellomo R, de Cal M, Polanco N, Corradi V, Lentini P, Nalesso F, Ueno T, Ranieri VM, Ronco C. Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care. 2007 Apr 20;11(2):R47 [Epub ahead of print]
11. Ueno T, Omura T, Takahashi T, Matsumoto H, Takahashi Y, Kakita A, Yamashina S. Liver transplantation using liver grafts preserved under high pressure. 2005; 29: 849-55.
12. Ito T＊, Ueno T＊, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H Jr, Sayegh MH, Najafian N. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 mediated alloimmune responses in vivo. J Immunol. 2005; 174: 6648-56. ＊; equal contribution
13. Ueno T, Sugino M, Nemoto H, Shoji H, Kakita A, Watanabe M. Effect over time of endotoxin adsorption therapy (PMX-DHP) in sepsis. Ther Apher Dial. 2005; 9: 128-36.
14. Sakamoto I, Takahashi T, Ueno T, Kakita A, Hayashi I, Yamashina S. Regeneration of Schwann cells during extrinsic hepatic reinnervation following liver transplantation in rats. Transplant Proc. 2003; 35: 573-4.
15. Ueno T, et al. Relation between Endtoxin Activity Assay (EAA) and procalcitonin -A case of with peritonitis after percutaneous endoxcopic gastrostomy (PEG) catheter replacement- Japan Journal of Critical Care for Endotoxemia. 2008. in press (in Japanese)
16. Ueno T, et al. Numbers of organ failure and HMGB-1 in septic shock patients. The Japanese Journal of Shock Society. 2008. in press (in Japanese)
17. Ueno T, et al. A case of septic ARDS after kidney transplantation. ICU & CCU. 2008; 32: 266-9. (in Japanese)
18. Ueno T, et al. Endotoxin adsorption therapy in severe sepsis and septic shock. Japan Journal of Critical Care for Endotoxemia. 2007; 11: 95-8. (in Japanese)
19. Ueno T, et al. A case of a severe group B streptococcal infection with hyperctokinemia. The Japanese Journal of Acute Medicine. 2007; 31: 2-4. (in Japanese)
20. Ueno T, et al. New insights into sepsis with endotoxin adsorption therapy. Prog Med. 2006; 26: 1639-46. (in Japanese)
21. Ueno T, Sugino M, Nemoto H, Kakita A, Watanabe M. Severity Evaluation of Acute Abdomen in the Lower Digestive Tract with Septic Severity Score. Kitasato Medicine. 2004; 34: 59-66. (in Japanese)
22. Ueno T, Sugino M, Hosono S, Nakamura T, Naito O, Nemoto H, Kakita A. Conditions for completion / withdrawal from acute blood purification therapy in abdominal diseases requiring emergent care. Journal of Abdominal Emergency Medicine 2003; 23: 27-36. (in Japanese)
23. Ueno T, Sugino M, Hosono S, Nakamura T, Naito O, Nemoto H, Kakita A. Two cases of panperitonitis due to perforation of the large intestine with DIC in which CHDF and PMX were combinedly used. Kitasato Medicine 2003 32, 221-5. (in Japanese)
［Abstracts］
1. Takaya Murayama, Katsunori Tanaka, Takuya Ueno, Mollie Jurewics, Guleria Indira, Fiorina Paolo, Paez Jesus, Smith N. Rex, Sayegh Mohamed, Reza Abdi. Divergent Role of Tissue/Donor Dendritic Cells in Rejection Versus Tolerance of Cardiac Allografts: Studies with CX3CR1-Deficient Mice. 2008 American Transplant Congress, Toronto, QC, Canada.
2. Takuya Ueno, Mollie Jurewicz, Katsunori Tanaka, Susan Shea, Paolo Fiorina, Rex N. Smith, Mohamed H. Sayegh, Reza Abdi. Divergent Role of Tissue/Donor Dendritic Cells in Rejection Versus Tolerance of Cardiac Allografts: Studies with CX3CR1 Deficient Mice. 2007 American Transplant Congress, San Francisco, CA, U.S.A.
3. R. Neal Smith, Takuya Ueno, Toshiro Ito, Katsunori Tanaka, Atsushi Izawa, Susan Shea, Mollie Jurewicz, Mohamed H. Sayegh, Reza Abdi. Chemokines and Chronic Heart Allograft Rejection. 2007 American Transplant Congress, San Francisco, CA, U.S.A.
4. Antje Habicht, Takuya Ueno, Monica Albin, Michael Clarkson, Hideo Yagita, Hisaya Akiba, David Rothstein, Nader Najafian, Mohamed Sayegh. The Novel TIM-1:TIM-4 Costimulatory Pathway Plays a Crucial Role in Regulation of Alloimmunity by Promoting Immunoregulatory Th2 Cytokines and Expansion of Regulatory T Cells In Vivo. 2007 American Transplant Congress, San Francisco, CA, U.S.A.
5. Takuya Ueno, Mollie Jurewicz, Katsunori Tanaka, Susan Shea, Negin Behazin, Paolo Fiorina, Hugh Auchincloss Jr., Mohamed H. Sayegh, Rex N. Smith, Reza Abdi. Targeting the CX3CR1 pathway in donors to impair generation of tissue DC; a novel strategy to manipulate donor DC to achieve prolongation of allograft survival in recipients. 2006 ASN Renal Week, San Diego, CA, U.S.A.
6. Takuya Ueno, M Javeed Ansari, Toshiro Ito, Leila Makhlouf, Mohamed H Sayegh, Hugh Auchincloss Jr. GENETIC BASIS OF RESISTANCE TO TRANSPLANTATION TOLERANCE INDUCTION IN NOD MICE. 2006 World Transplant Congress, Boston, MA, U.S.A.
7. Monica J Albin, Takuya Ueno, Michael R Clarkson, Antje Habicht, Nader Najafian, Mohammed H Sayegh. THE NOVEL T CELL ACTIVATION AND DIFFERENTIATION PATHWAY TIM-1 PLAYS A CRUCIAL ROLE IN REGULATION OF ALLOIMMUNE RESPONSES IN VIVO. 2006 World Transplant Congress, Boston, MA, U.S.A.
8. Atsushi Izawa, Takuya Ueno, Toshiro Ito, Mollie Jurewicz, Rex N Smith, Katsunori Tanaka, Nader Najafian, Hugh Auchincloss, Richard O Hynes, Mohamed H Sayegh, Reza Abdi. ROLES OF DONOR-DERIVED SELECTINS IN THE DEVELOPMENT OF BOTH ACUTE REJECTION AND GRAFT ARTERIOSCLEROSIS. 2006 World Transplant Congress, Boston, MA, U.S.A.
9. Mohammed Javeed Ansari, Paolo Fiorina, Shirine Dada, Subbulaxmi Trikudananthan, Indira Guleria, Takuya Ueno, Gordon Freeman, Mohamed H Sayegh. THE ROLE OF ICOS IN AUTO- AND ALLO- IMMUNE DESTRUCTION OF ISLETS IN NOD MICE. 2006 World Transplant Congress, Boston, MA, U.S.A.
10. Kazuhiro Yamaura, Atsushi Izawa, Monica J Albin, Mollie Jurewicz, Katsunori Tanaka, Michael R Clarkson, Takuya Ueno, Mohamed H Sayegh, Nader Najafian. A NOVEL ALLOANTIGEN SPECIFIC CD8+PD1+ REGULATORY T CELL INDUCED BY ICOS-B7H BLOCKADE IN VIVO. 2006 World Transplant Congress, Boston, MA, U.S.A.
11. T. Ueno , M. R. Clarkson, A. Habicht, A. Izawa, S. Fernandes, M. Jurewicz, H. Auchincloss, Jr., G. J. Freeman, M. H. Sayegh, N. Najafian. ROLE OF B7 HOMOLOG 3 (B7-H3) IN A MURINE MODEL OF SKIN AND CARDIAC ALLOGRAFT REJECTION. 2005 American Transplant Congress, Seattle, WA, U.S.A.
12. T. Ueno, M. R. Clarkson, M. Jurewitz, S. Fernandes, H. Yagita, H. Akiba, H. Auchincloss, Jr., A. Izawa, A. Habicht, R. Abdi, M. H. Sayegh, N. Najafian. THE EMERGING ROLE OF T-CELL IMMUNOGLOBULIN MUCIN 1 (TIM-1) IN ALLOIMMUNE RESPONSES IN VIVO. 2005 American Transplant Congress, Seattle, WA, U.S.A.
13. T. Ueno, T. Ito, A. Yamada, M. H. Sayegh, H. J. Winn, H. Auchincloss, Jr. THE LIMITS OF LINKED SUPPRESSION FOR REGULATORY T CELLS. 2005 American Transplant Congress, Seattle, WA, U.S.A.
14. A. Habicht, J.I Ansari, M. R. Clarkson, T. Ueno, X. Yuan, S. Fernandes, G. J. Freeman, M. H. Sayegh. THE NOVEL FUSION PROTEIN CD160IG PREVENTS SKIN AND CARDIAC ALLOGRAFT REJECTION. 2005 American Transplant Congress, Seattle, WA, U.S.A
15. A. Izawa, M. Jurewicz, T. Ueno, T. Ito, A. Lacy-Hulbert, T. Ito, R. N. Smith, N. Najafian, H. Auchincloss jr. R. O. Hynes, M. H. Sayegh, R. Abdi. DISSECTING THE IMPORTANCE OF DONOR AND RECIPIENT SELECTINS IN CARDIAC ALLOGRAFT REJECTION USING ELP -/- SELECTIN-DEFICIENT MICE. 2005 American Transplant Congress, Seattle, WA, U.S.A
16. T. Ueno, N. Najafian, A. Yamada, L. H. Glimcher, M. H. Sayegh, H. Auchincloss, Jr. ROLE OF NFAT TRANSCRIPTION FACTORS IN SKIN AND VASCULARIZED CARDIAC ALLOGRAFT REJECTION. 2004 American Transplant Congress, Boston, MA, U.S.A.
17. A. Izawa, M. R. Clarkson, A. D. Salama, T. Ueno, H. Yagita, A. H. Sharpe, G. J. Freeman, M. H. Sayegh, N. Najafian. GENERATION OF REGULATORY CD8+ T CELLS BY ICOS-B7H SIGNAL BLOCKADE IN VIVO. 2004 American Transplant Congress, Boston, MA, U.S.A.
18. T. Ueno, Omura T, Matsumoto H, Takahashi Y, Takahashi T, Kakita A. Super-cooling preservation under high-pressure of rat livers. 2003 5th European Congress of IHPBiA, Istanbul, Turkey.
19. Takahashi T, Itabashi K, Ito Y, T. Ueno, Kakita A. Urinary trypsin inhibitor exerts protective effects on the hepatic micro- vasculature in hypotensive brain-dead rats. 2002 37th Congress of the European Society for Surgical Research.
20. Ueno T, Ikeda T, Ikeda K, Suda S. [Symposium] Effectiveness of PMX-DHP in severe sepsis and septic shock. 2008 Japanese Society for Abdominal Emergency Medicine, Yokohama, JAPAN
21. Ueno T, Ikeda T, Ikeda K, Suda S. [Symposium] Relation between Endtoxin Activity Assay (EAA) and procalcitonin -A case of with peritonitis after percutaneous endoxcopic gastrostomy (PEG) catheter replacement-. 2007 The Japan Society of Critical Care for Endotoxemia, Fukuoka, JAPAN
22. Invited Speaker [Luncheon Seminar] PMX-DHP in severe sepsis and septic shock. 2007 Japanese Society for Apheresis, Fukuoka, JAPAN
23. Invited Speaker [Luncheon Seminar] Blood purification therapy for severe sepsis and septic shock. 2007 Asian Pacific Digestive Week, Kobe, JAPAN
24. Ueno T, Ikeda T, Ikeda K, Kuroki Y, Yokoyama T, Suda S. Organ failures and HMGB-1. 2007 Japanese Association for Acute Medicine, Osaka, JAPAN
25. Ueno T, Ikeda T, Ikeda K, Suda S, Hama K, Matsuno N. [Case report] a patient with septic ARDS after kidney transplantation. 2007 Japan Society for Blood Purification in Critical Care, Oita, JAPAN
26. Ueno T, Ikeda T, Ikeda K, Suda S, Asaumi T. [Case report] EAA and Procalcitonin in septic shock. 2007 EAA meeting, Tokyo, JAPAN
27. Ueno T, Ikeda T, Ikeda K, Kuroki Y, Yoshikawa K. [Symposium] Organ failures and HMGB-1. 2007 The Japan Shock Society, Shiga, JAPAN
28. Ueno T, Ikeda T, Ikeda K, Kuroki Y, Yoshikawa K. [Symposium] New insights into sepsis with endotoxin adsorption therapy. 2007 The Japan Society of Critical Care for Endotoxemia, Tokyo, JAPAN
29. T. Ueno, T. Omura, H. Matsumoto, Y. Takahashi, T. Takahashi, A. Kakita. [Poster Presentation] Liver transplantation using liver grafts preserved under high pressure. 2003 Journal of Japan Surgical Society, Sapporo, JAPAN.
30. T. Ueno, M. Sugino, H. Nemoto, A. Kakita. [Oral Presentation] Severity evaluation of acute abdomen in the lower digestive tract with septic severity score. 2003 The Japanese Society of Gastroenterological Surgery, Tokyo, JAPAN.
31. T. Ueno, T. Omura, H. Matsumoto, Y. Takahashi, T. Takahashi, A. Kakita. [Oral Presentation] Meaning of high pressure under supercooling preservation of rat livers. 2003 Japanese Liver Transplantation Society, Nagasaki, JAPAN.
And more than 30 abstracts as an author and a co-author have been published in several scientific journals from 1996 through 2002.